VEGFA Rabbit Polyclonal Antibody

CAT#: TA301750

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Rabbit Polyclonal Antibody against VEGFA



USD 430.00


Availability*
2 Weeks

Size
    • 100 ul


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Specifications

Product Data
Applications WB
Recommended Dilution WB: 1.0 ug/ml
Reactivity human, mouse, rat, porcine, hamster, horse, chicken, guinea porcine, dog, cow
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide made to an internal region of the human VEGFA protein sequence (between residues 150-250). [Swiss-Prot# P15692]
Formulation Tris-citrate/phosphate buffer, pH 7-8 and 0.1% sodium azide
Purification Affinity purified
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name vascular endothelial growth factor A
Background VEGFA is a member of the PDGF/VEGF growth factor family and is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.
Synonyms MVCD1; VEGF; VPF
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Bladder cancer, Cytokine-cytokine receptor interaction, Focal adhesion, mTOR signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, VEGF signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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