HIF1AN Rabbit Polyclonal Antibody
$620.00
In Stock*
Specifications
| Product Data | |
| Application | Electron Microscopy, ICC/IF, IHC, IP, WB |
|---|---|
| Recommended Dilution | Immunohistochemistry: 1:100, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation: 1:10-1:500, Electron Microscopy, Immunohistochemistry-Paraffin: 1:50-1:200, Immunohistochemistry-Frozen: 1:50-1:200, Western Blot: 1:1000-1:5000, Knockdown Validated, Knockout Validated |
| Reactivity | Human, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | A C-terminal region synthetic peptide made to the human FIH protein sequence (between residues 300 and the C-terminus). |
| Buffer | Tris-citrate/phosphate pH 7-8 buffer. and 0.1% Sodium Azide |
| Concentration | lot specific |
| Purification | Immunogen affinity purified |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | hypoxia inducible factor 1 alpha subunit inhibitor |
| Database Link | |
| Background | Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activity by binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alpha transactivation function by recruiting histone deacetylases. Involvement of VHL in association with FIH provides a unifying mechanism for the modulation of HIF-1 alpha protein stabilization and transcriptional activation in response to changes in cellular oxygen concentration. |
| Synonyms | FIH1 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.