ATG5(ATG5) Rabbit Polyclonal Antibody

CAT#: TA301481

Rabbit Polyclonal Antibody against ATG5

Antibody Service

 Product Datasheet for 'TA301481'

USD 474.00

2 Weeks

    • 100 ul

Product images


Product Data
Applications WB, IHC, IF
Recommend Dilution WB: 1:500
Reactivity human, mouse, rat, cow, porcine, primate, Xenopus, Zebrafish
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide made to an N-terminal region (within residues 1-50) of the human ATG5 protein. [Swiss-Prot# Q9H1Y0]
Isotype IgG
Formulation PBS plus 30% glycerol and 0.1% sodium azide
Concentration 1.16mg/ml
Purification peptide affinity purified
Gene Name autophagy related 5
Background Autophagy is an important mechanism for nonselective intracellular breakdown whereby cytosol and organelles are encapsulated in vesicles, which are then engulfed and digested by lytic vacuoles/lysosomes. ATG5 is required for autophagy. It conjugates to ATG12 and associates with isolation membrane to form autophagosomes. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Conjugation to ATG12 is essential for autophagy, but is not required for association with isolation membrane. ATG5 also plays an important role in the apoptotic process. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
Reference Data
Protein Families Druggable Genome
Protein Pathways Regulation of autophagy, RIG-I-like receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.