PGP9.5 (UCHL1) Rabbit Polyclonal Antibody

CAT#: TA301476

Rabbit Polyclonal Antibody against PGP9.5 - Peripheral Nerve Fiber marker

Product Images

Immunocytochemistry/Immunofluorescence: UCH-L1/PGP9.5 Antibody TA301476 - In Neuro2a cells with FITC (green). Nuclei were counterstained with DAPI (blue).

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  Immunohistochemistry: PGP9.5 / UCHL-1 Antibody TA301476 - Human brain, Substantia Nigra, Pigmented Neuron, 40X.

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  Western Blot: PGP9.5 / UCHL-1 Antibody TA301476 - Detection of UCHL1 in mouse brain lysate.

Specifications

Product Data

• Applications: ICC/IF, IHC, WB
• Recommended Dilution: Immunohistochemistry: 2.5-5.0 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:100-1:200, Western Blot: 0.5-2.0 ug/ml, Immunohistochemistry-Paraffin: 2.5-5.0 ug/ml
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide made to an internal portion of the human UCHL1 protein sequence (between residues 100-200). UniProt P09936
• Formulation: Tris-glycine and 150mM NaCl and 0.05% Sodium azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ubiquitin C-terminal hydrolase L1
• Database Link:
  NP_004172
  Entrez Gene 22223 MouseEntrez Gene 7345 Human
  UniProt ID P09936
• Background: UCHL1 is a soluble cytoplasmic protein with a molecular weight of approximately 25,000 kD. It is present in neurons and in cells of the diffuse neuroendocrine system. UCHL1 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme. This enzyme is also known as PGP9.5. Because of its abundance in nerves, it has been widely used as a marker for peripheral nerve fibers.
• Synonyms: HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Parkinson's disease