Thimet Oligopeptidase (THOP1) Mouse Monoclonal Antibody [Clone ID: 4D6]

CAT#: TA301468

Mouse Monoclonal Antibody against Thimet Oligopeptidase (4D6)

Product Images

Western Blot: Thimet Oligopeptidase Antibody (4D6) TA301468 - Detection of thimet oligopeptidase antibody in HeLa whole cell lysate (30 ug) using TA301468. Lane 1: 0.5 ug/ml; lane 2: 2 ug/ml. 1 minute ECL exposure.

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  Immunohistochemistry: Thimet Oligopeptidase Antibody (4D6) TA301468 - Analysis of Thimet Oligopeptidase in mouse brain using DAB with hematoxylin counterstain.

Specifications

Product Data

• Clone Name: 4D6
• Applications: ICC/IF, IHC, WB
• Recommended Dilution: Immunohistochemistry: 1:400, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Western Blot: 1:750-1:3000, Immunohistochemistry-Paraffin: 1:400
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues 56-72 of human thimet oligopeptidase.
• Formulation: Tris-glycine and 150mM NaCl and 0.05% sodium azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: thimet oligopeptidase 1
• Database Link:
  NP_003240
  Entrez Gene 7064 Human
  UniProt ID P52888
• Background: A steady-state level of amyloid beta-peptide (Abeta) represents a balance between its biosynthesis from the amyloid precursor protein (APP) through the action of the beta and gamma-secretases and its catabolism by a variety of proteolytic enxymes. Thimet Oligopeptidase (THOP1) has been shown to promote A-beta degradation. It has also been shown to play a role in antigen presentation, metabolism of neuropeptides under 20 amino acids, and cytoplasmic peptide degradation.
• Synonyms: EP24.15; MEPD_HUMAN; MP78; TOP

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Renin-angiotensin system