NGF Rabbit Monoclonal Antibody [Clone ID: EP1318Y]

CAT#: TA301201

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Rabbit Monoclonal Antibody against NGF (Clone EP1318Y)



USD 560.00


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In Stock

Size
    • 100 ul


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Specifications

Product Data
Clone Name EP1318Y
Applications WB
Recommended Dilution WB: 1: 1,000; ICC: 1: 100; FC: 1:200; IP: 1:20
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen A synthetic peptide corresponding to residues near the N-terminus of human NGF-beta precursor (pro-NGF) form was used as an immunogen. This antibody recognizes pro-NGF.
Formulation pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 27 kDa
Gene Name nerve growth factor
Background Nerve growth factor (NGF) stimulates division and differentiation of sympathetic and embryonic sensory neurons. NGF is thought to have a profound effect on the development and maintenance of sympathetic and embryonic sensory neurons (1). NGF activity isolated from the male mouse submaxillary gland (MSG) consists of three types of subunits, alpha, beta and gamma, which specifically interact to form a 7S, approximately 130,000-molecular weight (Mr) complex. The 7S complex contains two identical 118-amino acid beta-chains, which are solely responsible for the nerve growth-stimulating activity of NGF. While NGF is found in almost all vertebrates, most research has focused on murine NGF, as the mouse male submaxillary gland contains higher levels of this polypeptide than other tissues (2). A precursor form of NGF (pro-NGF) selectively binds to p75NTR receptor and leads to apoptosis with expression of TrkA and p75NTR . However, mature NGF binding to TrkA and p75NTR receptors shows opposite effect and leads to activation of cell survival (3).
Synonyms Beta-NGF; HSAN5; NGFB
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Apoptosis, MAPK signaling pathway, Neurotrophin signaling pathway
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