Cyclin D1 (CCND1) Rabbit Monoclonal Antibody [Clone ID: EPR2241]

CAT#: TA301123

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Rabbit Monoclonal Antibody against CCND1 (Clone EPR2241IHC)


 Product Datasheet for 'TA301123'

USD 534.00


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Size
    • 100 ul


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Specifications

Product Data
Clone Name EPR2241
Applications Assay, IHC, WB
Recommend Dilution WB: 1:10000; IP: 1:40; ICC/IF: 1:100; IHC-P: 1:100
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen A synthetic peptide corresponding to residues near the C-terminus of human Cyclin D1 was used as an immunogen.
Formulation pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Predicted Protein Size 34 kDa
Gene Name cyclin D1
Background Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition (1). Cyclin D1 forms a serine/threonine kinase holoenzyme complex with and functions as a regulatory subunit of CDK4 or CDK6. Cyclin D1 also phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1/S phase (2-3). Amplification or overexpression of cyclin D1 plays a pivotal role in the development of various human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer (4). Over-expression of cyclin D1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis (5). Cyclin D1 also associates with, and regulates the activity of transcription factors, coactivators and corepressors that govern histone acetylation and chromatin remodeling proteins (6-7)
Synonyms BCL1; D11S287E; PRAD1; U21B31
Note Is unsuitable for Flow Cyt.
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - Wnt Signaling pathway
Protein Pathways Acute myeloid leukemia, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, Focal adhesion, Glioma, Jak-STAT signaling pathway, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer, Thyroid cancer, Viral myocarditis, Wnt signaling pathway
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