Protein Phosphatase 1 beta (PPP1CB) Rabbit Monoclonal Antibody [Clone ID: EP1804Y]

CAT#: TA300926

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Rabbit Monoclonal Antibody against PPP1CB (Clone EP1804Y)



USD 524.00


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In Stock

Size
    • 100 ul


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Specifications

Product Data
Clone Name EP1804Y
Applications FC, IHC, WB
Recommended Dilution WB: 1:100000 - 1:200000; IP: 1:100; FC: 1:25; IHC-P: Use at an assay dependent dilution
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen A synthetic peptide corresponding to residues on human PP1 beta was used as an immunogen.
Formulation PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 37 kDa
Gene Name protein phosphatase 1 catalytic subunit beta
Background Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established or putative regulatory subunits (1). The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes. PP1 is ubiquitously distributed and regulates a broad range of cellular functions, including glycogen metabolism, cell-cycle progression and muscle relaxation. PP1 has evolved effective catalytic machinery but lacks substrate specificity. Substrate specificity is conferred upon PP1 through interactions with a large number of regulatory subunits (2). It has been shown that PP1 determines the efficacy of learning and memory by limiting acquisition and favoring memory decline. When PP1 is genetically inhibited during learning, short intervals between training episodes are sufficient for optimal performance (3).
Synonyms HEL-S-80p; PP-1B; PP1B; PP1beta; PPP1CD
Note Is unsuitable for ICC.
Reference Data
Protein Families Druggable Genome, Phosphatase
Protein Pathways Focal adhesion, Insulin signaling pathway, Long-term potentiation, Oocyte meiosis, Regulation of actin cytoskeleton, Vascular smooth muscle contraction
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