S100 beta(S100B) Rabbit Monoclonal Antibody [Clone ID: EP1576Y]

CAT#: TA300915

Rabbit Monoclonal Antibody against S100B (Clone EP1576Y)

Antibody Service


 Product Datasheet for 'TA300915'

USD 537.00


Availability*
In Stock

Size
    • 100 ul

Specifications

Product Data
Clone Name EP1576Y
Applications WB, IHC, Assay
Recommend Dilution ICC/IF: Use at an assay dependent dilution; WB: 1:1000; IP: 1:40; IHC-P: Use at an assay dependent dilution
Reactivity Mouse, Rat, Goat, Human, Zebrafish, Macaque Monkey
Host Rabbit
Clonality Monoclonal
Immunogen A synthetic peptide corresponding to residues on the C-terminus of human S100-ß was used as an immunogen.
Isotype IgG
Formulation PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Reconstitution Method Reconstitute with PBS (pH7.3). To use this carrier-free antibody for conjugation experiment, we strongly recommend you to perform another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Tissue culture supernatant
Predicted Protein Size 11 kDa
Gene Name S100 calcium binding protein B
Background S100-ß is a homodimeric member of the EF-hand calcium-binding protein superfamily. The protein has been implicated in cellular processes such as cell differentiation and growth, plays a role in cytoskeletal structure and function, and may have a role in neuropathological diseases, such as Alzheimers. The effects of S100-ß are mediated via its interaction with target proteins (1). S100-ß protein is a low molecular weight, EF-hand, Ca2(+)-binding protein widely distributed and conserved in the central nervous system of vertebrates (2). Measurements of Ca2+ binding to human brain S100-ß (beta beta) protein revealed six Ca2+-binding sites and zinc-binding studies on human S100b protein showed that the protein bound two zinc ions per beta monomer. These results indicate that the Ca2+- and Zn2+-binding sites on S100-ß protein are different and suggest that Zn2+ may regulate Ca2+ binding by increasing the affinity of the protein for calcium (3).
Synonyms NEF|S100|S100-B|S100beta
Note Is unsuitable for Flow Cyt.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.