CD63 Mouse Monoclonal Antibody [Clone ID: MEM-259]
Specifications
| Product Data | |
| Clone Name | MEM-259 |
|---|---|
| Application | FC, IF |
| Recommended Dilution | Indirect Immunofluorescence analysis by Flow Cytometry. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | HPB-ALL T cell line |
| Specificity | This antibody MEM-259 reacts with CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent. |
| Buffer | Phosphate Buffered Saline (PBS), pH~7.4 Label: Biotin State: Liquid purified Ig fraction Preservative: 15 mM Sodium Azide Label: LC-NHS under optimum conditions. The reagent is free of unconjugated Biotin |
| Concentration | lot specific |
| Conjugation | Biotin |
| Storage | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | CD63 molecule |
| Database Link | |
| Background | CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. It is also present in the plasma membrane, usually following cell activation. Hence, it has become an widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas. |
| Synonyms | OMA81H, Granulophysin, Tetraspanin-30, MLA1, TSPAN30, ME491 |
| Reference Data | |
| Protein Categories | CD Markers, Growth Factors, Membrane Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Lysosome |
Reviews
Documents
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.