Granzyme B (GZMB) Mouse Monoclonal Antibody [Clone ID: GB11]

CAT#: SM1806P

Granzyme B (GZMB) mouse monoclonal antibody, clone GB11, Purified

Specifications

Product Data

• Clone Name: GB11
• Applications: ELISA, FC, IF, IHC, IP
• Recommended Dilution: ELISA: 2-5 µg/ml.
  Immunoprecipitation.
  Immunofluorescence.
  Immunohistochemistry on Frozen Sections.
  Flow Cytometry: Use 10 µl of 1/10-1/100 diluted antibody to label 10⁶ cells or 100 µl whole blood (Membrane permeabilisation is required).
• Reactivities: Chimpanzee, Human, Monkey
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified human Granzyme B.
• Specificity: This antibody recognises the serine protease Granzyme B.
  This antibody has been reported to function as a Capture reagent in ELISA assays for soluble Granzyme B in conjunction with biotin conjugated clone GB10 (SM1805B) as detection reagent.
• Formulation: Tris buffered saline containing 0.09% Sodium Azide as preservative
  State: Purified
  State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: granzyme B
• Database Link:
  Entrez Gene 3002 Human
  UniProt ID P10144
• Background: Ganzyme B is important in the induction of apoptosis in target cells by cytolytic lymphocytes (CTLs). Granzyme B plays a key role in the induction of apoptosis by CTLs. After delivery to the target cell, Granzyme B activates the cascade of caspases that finally results in cell death.
• Synonyms: Granzyme-2, CGL1, CTSGL1, CSPB, CTLA1, CTLA-1, GRB, SECT, Fragmentin-2