Granzyme B (GZMB) Mouse Monoclonal Antibody [Clone ID: GB7]

CAT#: SM1804P

Granzyme B (GZMB) mouse monoclonal antibody, clone GB7, Purified

USD 409.00

5 Days*

    • 100 ug

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Product Data
Clone Name GB7
Applications IHC, WB
Recommended Dilution Western blot.
Immunohistochemistry on Paraffin Sections:
Requires antigen retrieval using heat treatment with Sodium Citrate buffer pH 6.0.
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Recombinant Granzyme B.
Spleen cells from immunised Balb/c mice were fused with cells of the mouse SP2/0 myeloma cell line
Specificity This antibody recognizes the serine protease Granzyme B, which is important in the induction of apoptosis in target cells by cytolytic lymphocytes (CTLs).
Formulation TRIS buffered saline, pH 8.0
State: Purified
State: Liquid purified IgG fraction from Tissue Culture Supernatant
Preservative: 0.01% Thiomersal
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name granzyme B
Background Granzyme A and Granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and they are stored within cytolytic granules and released by effector cells during degranulation. In activated CTLs, granzyme A and granzyme B are processed and activated by cathepsin C, and they then function to induce apoptosis by two distinct pathways.
Granzyme B proteolytically cleaves and activates members of the caspase family of cysteine proteases, including caspase-3, caspase-6, caspase-7 and caspase-9. When cleaved, these caspases assemble into active holoenzymes that then mediate apoptosis through a defined proteolytic cascade involving nuclear lamins and PARP (poly ADP ribose polymerase).
Granzyme A mediates the activation of apoptosis by inducing single-strand DNA breaks, membrane perturbation and nuclear condensations in an alternative pathway that is independent from caspase activation or the caspase proteolytic cascade.
Synonyms Granzyme-2, CGL1, CTSGL1, CSPB, CTLA1, CTLA-1, GRB, SECT, Fragmentin-2
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.