B-Cells (FMC7 Antigen) Mouse Monoclonal Antibody [Clone ID: FMC7]

CAT#: SM1303F

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B-Cells (FMC7 Antigen) mouse monoclonal antibody, clone FMC7, FITC



USD 841.00

5 Days*

Size
    • 100 Tests

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Specifications

Product Data
Clone Name FMC7
Applications FC
Recommended Dilution Flow Cytometry: Use 10 µl of neat antibody to label 10e6 cells or 100 µl whole blood.
Reactivities Human
Host Mouse
Isotype IgM
Clonality Monoclonal
Immunogen HRIK cells - Human B-Lymphoblastoid line.
Specificity This antibody recognizes a glycoprotein antigen of 105kD expressed by B lymphocytes. B-CLL is generally considered to be negative for FMC7 expression, but strong staining is seen in many other types of B cell lymphoma, including prolymphocytic leukaemia and hairy cell leukaemia. The expression pattern closely corresponds to that seen with CD22, but studies have shown that FMC7 does not recognise the CD22 molecule itself. A recent publication by Serke et al has shown that FMC7 recognises a conformational epitope on the CD20 molecule, most likely a multimeric complex of CD20.
Formulation TRIS buffered glycine containing 0.09% Sodium Azide and 0.2% BSA
Label: FITC
State: Liquid purified IgM
Label: Fluorescein Isothiocyanate Isomer 1
Purification Gel Filtration
Conjugation FITC
Storage Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Background The FMC7 antigen is expressed by peripheral B lymphocytes, and has been used widely in the study of B cell malignancy. FMC7 has been used extensively to differentiate various types of B cell malignancy. The nature of the FMC7 antigen has remained poorly defined following its first description in 1981.
Synonyms B-cell marker, B cells
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.