CD57 / HNK1 Mouse Monoclonal Antibody [Clone ID: TB01]
$470.00
5 Days*
Specifications
| Product Data | |
| Clone Name | TB01 |
|---|---|
| Application | FC, IHC |
| Recommended Dilution | Flow Cytometry: Use 10 µl of 1/50-1/100 diluted antibody to label 10e6 cells in 100 µl. Immunohistochemistry on Frozen Sections (1/10-1/100). Immunohistochemistry on Paraffin Sections (1/10-1/50): This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections but sodium citrate buffer may enhance staining. Recommended Positive Control: Human tonsil. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgM |
| Clonality | Monoclonal |
| Immunogen | Human neuroblastoma cells. Spleen cells from immunised BALB/c mice were fused with cells of the mouse P3.X63 Ag8.653 myeloma cell line. |
| Specificity | This antibody recognises the human CD57 molecule, expressed by NK cells and a subset of T cells. |
| Buffer | PBS, pH7.4 containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgM fraction. |
| Concentration | lot specific |
| Purification | Ion Exchange Chromatography. |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Background | CD57, also known as HNK-1, NK-1, and Leu-7, is a 100-115 kD oligosaccharide antigenic determinant expressed on a variety of proteins, lipids, and chondroitin sulfate proteoglycans. CD57 is expressed on a subset of peripheral blood lymphocytes, including NK cells and CD8+ T cells and is also expressed on neural cells and striated muscle. CD57 is not expressed on red cells, granulocytes, monocytes, or platelets.While the function of CD57 is unknown, binding to L-selectin, P-selectin, and a fragment of laminin suggests that CD57 may be involved in cell-matrix interactions. CD57 is increased in some disease states associated with CD4/CD8 imbalances (AIDS, autoimmune disease, viral infections, and allograft transplants). |
| Synonyms | HNK-1, LEU7, NK-1, NK-Cell marker, NK1 |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.