CD42a (GP9) Mouse Monoclonal Antibody [Clone ID: GRP-P]
Specifications
| Product Data | |
| Clone Name | GRP-P |
|---|---|
| Application | FC |
| Recommended Dilution | Flow Cytometry. |
| Reactivity | Canine, Human, Mink |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human red blood cells and platelets. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line. |
| Specificity | The mouse monoclonal antibody GR-P (also known as GRP-P) recognizes CD42a (glycoprotein 9), a 22 kDa transmembrane protein constitutively expressed on megakaryocytes and platelets. HLDA IV.; WS Code P 35. |
| Buffer | PBS, pH~7.4 Label: PE State: Lyophilized purified IgG fraction Stabilizer: 1% BSA, 5% Sucrose Preservative: 0.09% Sodium Azide Label: R. Phycoerythrin (RPE) |
| Reconstitution Method | Restore with 1 ml distilled water |
| Purification | Ion Exchange Chromatography |
| Conjugation | PE |
| Storage | Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | glycoprotein IX platelet |
| Database Link | |
| Background | CD42a, also known as Glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and Pselectin. Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. |
| Synonyms | Platelet glycoprotein IX, GP-IX, GP9 |
| Reference Data | |
| Protein Categories | Cardiovascular diseases, CD Markers, Membrane Proteins |
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Citations
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