CD13 (ANPEP) Mouse Monoclonal Antibody [Clone ID: WM15]

CAT#: SM1070BT

CD13 (ANPEP) mouse monoclonal antibody, clone WM15, Biotin

Product Images

Surface staining of human peripheral blood leukocytes with anti-CD13 (WM15) biotin, streptavidin-APC.

Specifications

Product Data

• Clone Name: WM15
• Applications: FC
• Recommended Dilution: Indirect immunofluorescence analysis by Flow cytometry.
• Reactivities: Human, Primate
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human AML cells
• Specificity: This antibody detects CD13 cell surface glycoprotein, a 150 kDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors.
• Formulation: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
  Label: Biotin
  State: Liquid purified Ig fraction
  Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
• Concentration: lot specific
• Conjugation: Biotin
• Storage: Store the antibody at 2 - 8 °C. DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Gene Name: alanyl aminopeptidase, membrane
• Database Link:
  Entrez Gene 290 Human
  UniProt ID P15144
• Background: CD13 (aminopeptidase N, APN) is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas.
• Synonyms: Aminopeptidase N, ANPEP, APN, PEPN

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protease, Transmembrane
• Protein Pathways: Glutathione metabolism, Hematopoietic cell lineage, Metabolic pathways, Renin-angiotensin system