TIP120A (CAND1) Rabbit Polyclonal Antibody

CAT#: R1506

TIP120A (CAND1) rabbit polyclonal antibody, Serum


USD 662.00

3 Days*

Size
    • 100 ul

Product Images

Other products for "CAND1"

Specifications

Product Data
Applications ELISA, IP, WB
Recommended Dilution Western blot (1:500-1:1,000).
Immunoprecipitation: The antibody immunoprecipitates in vitro translated protein and protein from cell lysates (using HeLa and NIH-3T3, and others). Coimmunoprecipitation of related proteins has not been tested. A 136.4 kDa band corresponding to human CAND1 is detected. Most cell lines expressing CAND1 can be used as a positive control.
ELISA: (1:2,000-1:10,000).
Reactivities Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 11-24 of Human CAND1/TIP120A (N-terminal) coupled to KLH.
Specificity This product is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.
This antibody reacts with human, rat and mouse CAND1/TIP120A.
Cross reactivity does occur with human, rat and mouse CAND2/TIP120B.
Cross reactivity with CAND1 from other sources is not known.
Formulation State: Serum
State: Liquid (sterile filtered) containing 0.01% (w/v) Sodium Azide as preservative.
Concentration lot specific
Purification Delipidation and defibrination.
Conjugation Unconjugated
Storage Store vial at -20°C prior to opening.
Aliquot contents and freeze at -20°C or below for extended storage. Centrifuge product if not completely clear after standing at room temperature.
This product is stable for one month at 2-8°C as an undiluted liquid. Dilute only prior to immediate use.
Avoid cycles of freezing and thawing.
Stability Shelf life: one year from despatch.
Background CAND1 is also known as TIP120A, and TATA-binding protein-interacting protein 120A. The SCF complex consists of the invariable components Skp1, Cul1, and Rbx1 as well as a variable F-box protein, and functions as an E3 ubiquitin ligase. E3 ubiquitin ligases regulate various physiological processes. CAND1 binds to Cul1 and potentially regulates the SCF complex. CAND1 physically associates with Cul1 in the nucleus and this interaction is mediated by a central region of Cul1 distinct from its binding sites for Skp1 and Rbx1. CAND1 selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation. CAND1 forms a ternary complex with CUL1 and ROC1.
Synonyms KIAA0829, TIP120, TIP120A, p120 CAND1
Reference Data

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.