Cystatin C (CST3) Rabbit Polyclonal Antibody

CAT#: DP2003

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Cystatin C (CST3) rabbit polyclonal antibody, Aff - Purified



USD 477.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications ELISA, WB
Recommended Dilution ELISA.
Western Blot.
Reactivities Human
Host Rabbit
Clonality Polyclonal
Immunogen Cystatin C from Human urine.
Specificity The antibody recognizes Human Cystatin C.
Other species not tested.
Formulation Azide Free 0.05M Phosphate buffer, 0.1M NaCl, pH 7.2
State: Aff - Purified
State: Lyophilized purified IgG fraction
Preservative: None
Reconstitution Method Restore with 0.1 ml of deionized water and let the lyophilized pellet dissolve completely.
Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
Concentration 1.0 mg/ml (after reconstitution)
Purification Immunoaffinity Chromatography on a column with immobilized Human Cystatin C
Conjugation Unconjugated
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Cystatin C is a non-glycosilated basic single-chain protein consisting of 120 amino acids with a molecular weight of 13.36 kDa and is characterized by two disulfide bonds in the carboxy-terminal region. It belongs to the cystatins superfamilly which inactivates lysosomal cysteine proteinases, e.g. cathepsin B, H,.K, L and S. Imbalance between Cystatin C and cysteine proteinases is associated with inflammation, renal failure, cancer, Alzheimers disease, multiple sclerosis and hereditary Cystatin C amyloid angiopathy. Its increased level has been found in patients with autoimune diseases, with colorectal tumors and in patients on dyalisis. Serum Cystatin C seems to be better marker of glomerular filtration rate than creatinine. On the other hand, low concentration of Cystatin C presents a risk factor for secondary cardiovascular events.
Synonyms Cystatin C, Cystatin-3, CST3
Note Quality Control Test:
Indirect ELISA to determine titer of the antibody.
SDS PAGE to determine purity of the antibody.
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.