Gastrin (GAST) Rabbit Polyclonal Antibody

CAT#: DP044

Gastrin (GAST) rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: Immunohistochemistry on formalin-fixed paraffin embedded sections:
  diluted of 1:50-1:100 in an ABC method (30 minutes at room temperature)
  Recommended Positive Control: Stomach
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant Gastrin conjugated to KLH.
• Specificity: The antibody is specific against gastrin-containing cells. This antibody reacts with human gastrin I and human gastrin I fragments.
  Cellular Localization: Cytoplasmic
• Formulation: containing sodium azide as preservative
  State: Purified
  State: Liquid serum
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: gastrin
• Database Link:
  Entrez Gene 2520 Human
  UniProt ID P01350
• Background: Gastrin is mainly known by its first described role as a gastric acid-hormone but the protein also has the ability to promote cellular growth. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect. Gastrin has two biologically active peptide forms, G34 and G17 and they activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of gastrin.
• Synonyms: GAST, GAS