CCL3 Mouse Monoclonal Antibody [Clone ID: 103]
Specifications
| Product Data | |
| Clone Name | 103 |
|---|---|
| Application | ELISA, WB |
| Recommended Dilution | ELISA. Western Blot. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Purified recombinant Human MIP1 alpha. |
| Specificity | This antibody reacts with recombinant MIP1 alpha. Does not show any cross reaction with other human cytokines or growth factors tested such as M-CSF, GM-CSF, IL-7, IL-8, IL-16, IL1 beta, bFGF, TGF beta, EGF, TNF alpha and EPO. |
| Buffer | 0.01M PBS, pH 7.2 without preservatives. State: Purified State: Lyophilized purified IgG fraction. |
| Reconstitution Method | Restore with double distillated water to adjust the final concentration to 1.0 mg/ml. |
| Purification | Affinity Chromatography on Protein G. |
| Conjugation | Unconjugated |
| Storage | Store the antibody at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Gene Name | C-C motif chemokine ligand 3 |
| Database Link | |
| Background | Macrophage Inflammatory Protein 1 alpha (MIP1 alpha) and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. Has adhesive effects on lymphocytes. MIP1 alpha can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. A signal transducing receptor, designated the C-C chemokine receptor-1 (C-C CKR-1) with seven transmembrane domains that bind MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities, has been isolated. |
| Synonyms | CCL-3, MIP-1-alpha, C-C motif chemokine 3, MIP1A, Small-inducible cytokine A3, SCYA3, LD78 alpha, G0S19-1 protein |
| Reference Data | |
| Protein Categories | Chemokines, Cytokines, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway |
Reviews
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.