CD49b (ITGA2) Human Monoclonal Antibody [Clone ID: B4F12]
$1,280.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | B4F12 |
|---|---|
| Application | FC, IF |
| Recommended Dilution | IF, ELISA, preferential detection of activated platelet by flow cytometry, platelet aggregation studies. Usage recommendation: *This monoclonal antibody may be used between 5-25μg/ml. *Optimal dilution should be determined by each laboratory for each application. *Coupled antibody: to maintain RT before use. |
| Reactivity | Human |
| Antibody Host | Human |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | CD40 activated and EBV immortalized human B lymphocytes |
| Specificity | GPIa-IIa preferentially on acitvated platelets. |
| Buffer | 100 μg in 200 μl / 50 μg in 100 μl PBS 50% glycerol Label: Alexa Fluor 488 |
| Concentration | lot specific |
| Purification | QMA Hyper D ion exchange chromatography |
| Conjugation | Alexa Fluor 488 |
| Storage | -20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
| Shipping | Blue Ice |
| Gene Name | integrin subunit alpha 2 |
| Database Link | |
| Background | Neonatal AlloImmune Thrombocytopenia (NAIT) is the commonest cause of severe isolated thrombocytopenia in the foetus and newborn. In Caucasians, 97% of NAIT are caused by HPA-1a or HPA- 5b alloantibodies. B4F12 was isolated after combination of CD40 activation and Epstein-Barr virus transformation of B cells isolated from a woman with high titre of anti -HPA-5b alloantibodies. B4F12 human monoclonal antibody recognizes GPIa-IIa preferentially on activated human platelets (Mérieux Y, Rigal D, Pin JJ, XVIIth Regional Congress, International Society of Blood Transfusion, Madrid 2007 ; Guillot-Chene P, Lebecque S, Rigal D, Annales Pharmaceutiques Françaises, 06/2009, 67 (3) 182-6). |
| Synonyms | Integrin alpha-2, ITGA-2, VLA-2 alpha, VLA2, GPIa, Collagen Receptor |
| Reference Data | |
| Protein Categories | Cardiovascular diseases, CD Markers, Membrane Proteins |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.