IGSF6 Mouse Monoclonal Antibody [Clone ID: 104A10.01]
Specifications
| Product Data | |
| Clone Name | 104A10.01 |
|---|---|
| Application | FC, WB |
| Recommended Dilution | Flow Cytometry surface, Western Blot. Usage recommendation: *This monoclonal antibody may be used between 5-15 μg/ml. *Optimal dilution should be determined by each laboratory for each application. *Coupled antibody: to maintain RT before use. |
| Reactivity | Canine, Human, Mouse |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant DORA Ig fusion protein. |
| Specificity | Human DORA. Species cross-reactivity: Mouse, Canine. |
| Buffer | Purified: 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8. Coupled: 100 μg in 200 μl / 50 μg in 100 μl PBS 50% glycerol. Label: Alexa Fluor 647 |
| Concentration | lot specific |
| Purification | QMA Hyper D ion exchange chromatography |
| Conjugation | Alexa Fluor 647 |
| Storage | -20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
| Shipping | Blue Ice |
| Gene Name | immunoglobulin superfamily member 6 |
| Database Link | |
| Background | Using a cDNA subtraction technique, a novel member of the immunoglobulin superfamily was isolated from human dendritic cells (DCs). This cDNA, named DORA, for Down-Regulated by Activation encodes a protein belonging to the CD8 family of receptors containing a single V type loop domain with an associated J chain region, a transmembrane region containing an atypical tyrosine residue and a cytoplasmic domain containing three putative tyrosine phosphorylation sites. The human DORA gene has been mapped to chromosome 16. Expression is observed in DCs, purified ex vivo or generated in vitro from either monocytes or CD34+ progenitors, and down-regulated following activation by PMA and Ionomycin or by CD40L engagement. (Bates EE et al, 2000; Immunogenetics, 52: 112-20; Bates EE et al, 1998; Mol. Immunology, 35: 513-24). |
| Synonyms | DORA |
| Reference Data | |
| Protein Categories | Membrane Proteins |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.