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PD-L1 (CD274) Mouse Monoclonal Antibody [Clone ID: OTI4G4]

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SKU
CF812995
Carrier-free (BSA/glycerol-free) CD274 mouse monoclonal antibody,clone OTI4G4
Size:
100 ug
Formulation:
Carrier-free Standard
Conjugation:
Unconjugated
  $620.00
3 Days*
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View other "PD-L1 or NM_014143" antibodies

Specifications
Specifications
Product Data
Clone Name OTI4G4
Application FC, WB
Recommended Dilution WB 1:500, FLOW 1:100
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human CD274 (NP_054862) produced in HEK293T cell.
Buffer Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Predicted Protein Size 33.28 kDa
Gene Name CD274 molecule
Database Link
Background This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. provided by RefSeq, Sep 2015
Synonyms B7-H; B7H1; hPD-L1; PD-L1; PDCD1L1; PDCD1LG1; PDL1
Reference Data
Protein Categories ADC Targets, CAR-T Targets, CD Markers, Cytokines, Membrane Proteins
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs)
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Documents
Resources
Other "OTI4G4" antibodies (4)
SKU Description Size Price
TA812995 CD274 mouse monoclonal antibody,clone OTI4G4 100 ul
$447.00
TA812995AM CD274 mouse monoclonal antibody,clone OTI4G4, Biotinylated 100 ul
$509.00
TA812995BM CD274 mouse monoclonal antibody,clone OTI4G4, HRP conjugated 100 ul
$509.00
TA812995S CD274 mouse monoclonal antibody,clone OTI4G4 30 ul
$200.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.