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DIP13B (APPL2) Mouse Monoclonal Antibody [Clone ID: OTI8F1]

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SKU
CF812391
Carrier-free (BSA/glycerol-free) APPL2 mouse monoclonal antibody,clone OTI8F1
Size:
100 ug
Formulation:
Carrier-free Standard
Conjugation:
Unconjugated
  $620.00
3 Days*
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View other "DIP13B or NM_018171" antibodies

Specifications
Specifications
Product Data
Clone Name OTI8F1
Application WB
Recommended Dilution WB 1:2000
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Full length human recombinant protein of human APPL2 (NP_060641) produced in HEK293T cell.
Buffer Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Predicted Protein Size 74.3 kDa
Gene Name adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Database Link
Background The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. provided by RefSeq, Oct 2011
Synonyms DIP13B
Reference Data
Protein Categories Cytokines, Growth Factors, Intracellular Proteins
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Resources
Other "OTI8F1" antibodies (4)
SKU Description Size Price
TA812391 APPL2 mouse monoclonal antibody,clone OTI8F1 100 ul
$447.00
TA812391AM APPL2 mouse monoclonal antibody,clone OTI8F1, Biotinylated 100 ul
$509.00
TA812391BM APPL2 mouse monoclonal antibody,clone OTI8F1, HRP conjugated 100 ul
$509.00
TA812391S APPL2 mouse monoclonal antibody,clone OTI8F1 30 ul
$200.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.