CD45 (PTPRC) Mouse Monoclonal Antibody [Clone ID: UCH-L1]

CAT#: CF807197

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Carrier-free (BSA/glycerol-free) CD45RO mouse monoclonal antibody, clone UCH-L1



USD 545.00


Availability*
In Stock

Size
    • 100 ug


Specifications

Product Data
Clone Name UCH-L1
Applications FC, IHC
Recommended Dilution IHC 1:150
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen IL-2-dependent T-cell line (CA1).
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name Homo sapiens protein tyrosine phosphatase receptor type C (PTPRC), transcript variant 2, mRNA.
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
Synonyms B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Phosphatase, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs), Fc gamma R-mediated phagocytosis, Primary immunodeficiency, T cell receptor signaling pathway
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