Asialoglycoprotein Receptor 2 (ASGR2) Mouse Monoclonal Antibody [Clone ID: OTI2A12]

CAT#: CF505099

Carrier-free (BSA/glycerol-free) ASGR2 mouse monoclonal antibody, clone OTI2A12 (formerly 2A12)

Formulation: Standard Carrier-Free



  View other "OTI2A12" antibodies (4)

USD 600.00

In Stock*

Size
    • 100 ug

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Specifications

Product Data
Clone Name OTI2A12
Applications IHC, WB
Recommended Dilution WB 1:4000, IHC 1:150
Reactivities Human
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Full length human recombinant protein of human ASGR2 (NP_001172) produced in HEK293T cell.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 35 kDa
Gene Name Homo sapiens asialoglycoprotein receptor 2 (ASGR2), transcript variant 1, mRNA.
Background This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Synonyms ASGP-R2; ASGPR2; CLEC4H2; HBXBP; HL-2
Reference Data
Protein Families Druggable Genome, Transmembrane

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