Cytochrome P450 17A1(CYP17A1) Mouse Monoclonal Antibody [Clone ID: OTI5G10]
Carrier-free (BSA/glycerol-free) CYP17A1 mouse monoclonal antibody, clone OTI5G10 (formerly 5G10)
Product Datasheet for 'CF503415'
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|Recommend Dilution||WB 1:2000,|
|Immunogen||Full length human recombinant protein of human CYP17A1(NP_000093) produced in HEK293T cell.|
|Formulation||PBS (pH7.3), 8% Trehalose|
|Reconstitution Method||Reconstitute with PBS (pH7.3). To use this carrier-free antibody for conjugation experiment, we strongly recommend you to perform another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)|
|Purification||Purified from cell culture supernatant by affinity chromatography|
|Predicted Protein Size||57.2 kDa|
|Gene Name||Homo sapiens cytochrome P450 family 17 subfamily A member 1 (CYP17A1)|
|Background||This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq].|
|Synonyms||CPT7; CYP17; P450C17; S17AH|
|Protein Families||P450, Druggable Genome|
|Protein Pathways||C21-Steroid hormone metabolism, Metabolic pathways|