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SAMHD1 Mouse Monoclonal Antibody [Clone ID: OTI3F5]

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SKU
CF502024
Carrier-free (BSA/glycerol-free) SAMHD1 mouse monoclonal antibody, clone OTI3F5 (formerly 3F5)
Size:
100 ug
Formulation:
Carrier-free Standard
Conjugation:
Unconjugated
  $620.00
3 Days*
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View other "SAMHD1 or NM_015474" antibodies

Specifications
Specifications
Product Data
Clone Name OTI3F5
Application FC, IF, IHC, WB
Recommended Dilution WB 1:200~500, IHC 1:150, IF 1:100, FLOW 1:100
Reactivity Human, Monkey, Mouse, Rat
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Full length human recombinant protein of human SAMHD1(NP_056289) produced in HEK293T cell.
Buffer Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Ambient
Predicted Protein Size 72 kDa
Gene Name SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Database Link
Synonyms CHBL2; DCIP; HDDC1; MOP-5; SBBI88
Reference Data
Protein Categories Immune system diseases, Intracellular Proteins
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Other "OTI3F5" antibodies (4)
SKU Description Size Price
TA502024 SAMHD1 mouse monoclonal antibody, clone OTI3F5 (formerly 3F5) 100 ul
$447.00
TA502024AM SAMHD1 mouse monoclonal antibody, clone OTI3F5 (formerly 3F5), Biotinylated 100 ul
$509.00
TA502024BM SAMHD1 mouse monoclonal antibody, clone OTI3F5 (formerly 3F5), HRP conjugated 100 ul
$509.00
TA502024S SAMHD1 mouse monoclonal antibody, clone OTI3F5 (formerly 3F5) 30 ul
$200.00

file-alt Citations

Large-scale drug sensitivity, gene dependency, and proteogenomic analyses of telomere maintenance mechanisms in cancer cells
Wu, Cai, Cross et al
Nat Commun (2025) 16 (1), 11337 DOI: 10.1038/s41467-025-67190-w
Cited by 6
AI Summary: In this study, OriGene’s anti-SAMHD1 antibody (Cat# TA502024) was used for protein detection, contributing to the analysis of telomere maintenance mechanisms in cancer cells.
Snippet: analyzer (LAS-4000, Fujifilm). Primary antibodies: anti-ATRX at 1:400 dilution (Cat#HPA064684 Sigma), anti-DAXX at 1:750 dilution (Cat#HPA008736 Sigma), anti-SAMHD1 at 1:500 dilution (Cat# TA502024, OriGene Technologies Inc.) and anti-Actin at 1:500 dilution (Cat#A2066 Sigma). Secondary antibodies: Goat Anti-Rabbit Immunoglobulins/HRP (1:5000) (Cat# P0448 Agilent) and Goat Anti-Mouse Immunoglobul
FigureFigureFigure
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks
Kapoor-Vazirani, Rath, Liu et al
Nat Commun (2022) 13 (1), 6707 DOI: 10.1038/s41467-022-34578-x
Cited by 28
AI Summary: In this study, OriGene products—including the SAMHD1 Myc-DDK tagged cDNA (RC200807) and SIRT1 Myc-DDK tagged cDNA (RC208447)—were used to express and analyze the roles of SAMHD1 and SIRT1 in DNA double-strand break repair mechanisms.
Snippet: ing to nucleic acids and localization to DNA damage sites are unclear. Sirtuins are NAD+ dependent deacetylases, which regulate multiple biological processes, including genome maintenance, aging, tumorigenesis, and metabolism73–80. There are 7 mammalian homologs of yeast Sir2 that exhibit distinct subcellular localization, with SIRT1, SIRT6, and SIRT7 localized to the nucleus, SIRT2 residing mo
FigureFigureFigure
Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses
Albanese, Ruhle, Mittermaier et al
Nat Methods (2021) 19 (1), 81-89 DOI: 10.1038/s41592-021-01328-8
Cited by 42
AI Summary: In this study, the OriGene anti-SAMHD1 antibody (mouse, clone OTI3F5, cat. no. TA502024) was used to detect SAMHD1 protein levels, enabling the functional analysis of gene-edited resting CD4+ T cells.
Snippet: …no. 14326S) 1:1,000 dilution, anti-SAMHD1 (mouse, clone OTI3F5, Origene, cat. … TA502024) 1:250 dilution and anti-GFP (rabbit polyclonal, Chromoteck, PABG1-20) 1:1,000 dilution. …no. 14326S) 1:1,000 dilution, anti-SAMHD1 (mouse, clone OTI3F5, Origene, cat. … TA502024) 1:250 dilution and anti-GFP (rabbit polyclonal, Chromoteck, PABG1-20) 1:1,000 dilution
WB
Specific Deubiquitinating Enzymes Promote Host Restriction Factors Against HIV/SIV Viruses
Gao, Rui, Li et al
Front Immunol (2021) 12, 740713 DOI: 10.3389/fimmu.2021.740713
Cited by 10
AI Summary: OriGene products, specifically the USP8 (RC217863) and USP21 (RC220833) expression plasmids, were used in this study to ectopically express deubiquitinating enzymes and investigate their roles in inhibiting HIV/SIV viral protein-mediated degradation of host restriction factors.
FigureFigureFigure
SAMHD1 inhibits multiple Enteroviruses by interfering with the interaction between VP1 and VP2 proteins
Zhao, Li, Huan et al
J Virol (2021)
AI Summary: In this study, the anti-SAMHD1 monoclonal antibody from OriGene (catalog no. TA502024) was used to detect and analyze SAMHD1 protein expression, enabling the investigation of its antiviral mechanism against multiple enteroviruses.
Snippet: no. 05-724), anti-tubulin mAb (Abcam, Cambridge, Cambridgeshire, UK, catalog no. 351 ab11323), anti-Flag mAb (Sigma, catalog no. F1804), anti-SAMHD1 mAb (Origene, 352 catalog no. TA502024). For confocal microscopy, goat anti-Mouse IgG (H+L) Highly Cross
WB
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity
Li, Huan, Wang et al
EMBO Rep. (2019) 21 (1), e47528 DOI: 10.15252/embr.201847528
Cited by 76
AI Summary: OriGene products, specifically the anti-BST2 polyclonal antibody (TA310217) and the anti-SAMHD1 monoclonal antibody (TA502024), were used in this study to detect and analyze the expression of BST2 and SAMHD1 proteins, supporting the investigation of TRIM21-mediated regulation of SAMHD1’s antiviral activity.
Snippet: …F1804), anti‐BST2 pAb (OriGene, catalog no. TA310217), anti‐SAMHD1 mAb (OriGene, catalog no. TA502024), anti‐Phospho‐SAMHD1 (Thr592) mAb (Prosci, Poway, catalog no. 8005), anti‐TRIM21 pAb (Proteintech, catalog no. 12108‐1‐AP)
WB
Showing 1-6 of 13 papers.
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