TRPM4 Mouse Monoclonal Antibody [Clone ID: OTI10H5]

CAT#: CF500381

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Carrier-free (BSA/glycerol-free) TRPM4 mouse monoclonal antibody, clone OTI10H5 (formerly 10H5)


Product Datasheet for 'CF500381'


  View other "OTI10H5" antibodies (2)

USD 465.00


Availability*
In Stock

Size
    • 100 ug


Specifications

Product Data
Clone Name OTI10H5
Applications IHC, WB
Recommended Dilution WB 1:5000~10000, IHC 1:50
Reactivity Human, Monkey, Dog
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Predicted Protein Size 134.3 kDa
Gene Name Homo sapiens transient receptor potential cation channel subfamily M member 4 (TRPM4), transcript variant 1, mRNA.
Background Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
Synonyms hTRPM4; LTrpC4; PFHB1B; TRPM4B
Reference Data
Protein Families Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane

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