alpha 2 Macroglobulin (A2M) Sheep Polyclonal Antibody

CAT#: BP611

alpha 2 Macroglobulin (A2M) sheep polyclonal antibody, Ig Fraction

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: Immunohistochemistry on frozen sections (1:20 - 1:200).
  ELISA.
• Reactivities: Human
• Host: Sheep
• Clonality: Polyclonal
• Immunogen: Native Alpha-2 Macroglobulin
• Specificity: This antibody detects alpha-2-Macroglobulin.
• Formulation: PBS, pH 7.2, 0.09 % Sodium Azide
  State: Ig Fraction
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Ammonium Sulphate fractionation
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C up to one week or (in aliquots) at -20 °C for longer. Centrifuge vial before opening. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 2 Human
  UniProt ID P01023
• Background: Alpha 2 macroglobulin is a serum protein which is mainly synthesised in the liver. It functions as a broad range irreversible proteinase inhibitor that forms a "trap" around most proteases. Alpha 2 macroglobulin is a tetrameric molecule, and with a molecular weight of 720 kDa, it so large a molecule that it tends to remain intravascular. Following conformational change the proteinase is deposited within a central cavity where it is still active but prevented from further contact with its substrate. Removal of the complex is mediated by the generation of recognition sites which react with receptors on a variety of cells including macrophages and liver cells. Alpha 2 macroglobulin is localized on the surface of peripheral blood lymphocytes.
• Synonyms: Alpha-2-M, CPAMD5, Alpha 2 macroglobulin