Plakophilin 3 (PKP3) Mouse Monoclonal Antibody [Clone ID: 12B11F8]
Mouse Monoclonal Anti-PKP3 Antibody, Purified
Product Datasheet for 'BM6030P'
|Recommend Dilution||ICC/IF, IHC, WB, IP|
|Reactivity||Canine, Human, Mouse, Porcine|
|Immunogen||Synthetic peptide corresponding to amino acid residues 779-793 of Human Plakophilin-3 coupled to keyhole limpet hemocyanin via an additional cysteine residue at the N-terminus (CKLHRDFAKGYRKED).|
|Formulation||PBS with 0.09% Sodium Azide as preservative.|
|Purification||Liquid purified IgG fraction.
|Predicted Protein Size||86.9 kDa|
|Gene Name||plakophilin 3|
|Background||Plakophilin-3 is an Armadillo-like protein present in nuclei and desmosomes of epithelial cells . The expression pattern of this protein seems to be largely restricted to epithelial cell types. Plakophilin-3 can be detected along cell borders in a punctuate staining pattern typical for desmosomal proteins. In addition to the desmosomal immunolocalisation, immunostaining was observed as bright nuclear speckles. Thus, like plakophilin-1 and-2, plakophilin-3 displays a dual intracellular localisation in the desmosomal plaque and in the cell nucleus, and therefore is probably involved in signal transduction pathways between the plasma membrane and the nucleus. The human protein has a predicted molecular mass of 87 kD.|
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