EMAP II (AIMP1) Mouse Monoclonal Antibody [Clone ID: 546-2]

CAT#: BM4115S

Reviews ()
Write a review

EMAP II (AIMP1) mouse monoclonal antibody, clone 546-2, Purified



USD 451.00


Availability*
2 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Clone Name 546-2
Applications ELISA, FC, IHC, WB
Recommended Dilution Flow cytometry: The typical starting working dilution is 1:10.
Immunoassays.
Immunhistochemistry on paraffin sections: The typical starting working dilution is 1:10.
Western blot: The typical starting working dilution is 1:10.
Reactivity Human, Rat
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Specificity

Monoclonal antibody 546-2 reacts with endothelial-monocyte-activating polypeptide II (EMAP II), a 20 kDa polypeptide.

Formulation PBS
State: Purified
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% bovine serum albumin
Preservative: 0.02% sodium azide
Concentration lot specific
Purification Protein G
Conjugation Unconjugated
Storage

Store at 2 - 8 °C.

Stability Shelf life: one year from despatch.

Background EMAP II is an antiangiogenic and proinflammatory cytokine (expressed by microglia/macrophages). EMAP II appears to be a profound modulator of inflammatory reactions of the innate immune system and might participate in a variety of pathogenic immune-processes in the mammalian brain. EMAP II is a potential mediator of inflammatory responses in autoimmunity and a considered target to stage reactions of monocytic lineage cells in inflammatory reactions. In normal tissues EMAP II is expressed in endocrine organs, in cells of neuroendocrine origin, but also in tissues with high cell turnover. Under pathophysiological conditions EMAP II has several functions. It triggers the recruitment of macrophages by elevating cytosolic-free Ca2+ concentrations, it stimulates leukocyte chemotaxis, it induces the expression of TNF-alpha and tissue factor (TF) by monocytes and myeloperoxidase (MPO) by polymorphonuclear cells (PNMs). Furthermore it stimulates the release of von Willebrand-factor, P- and E-selectin by endothelial cells and EMAP II induces endothelial programmed cell death in vitro.
Synonyms EMAP-2, EMAP-II, AIMP1
Reference Data
Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Antibody Performance Guarantee banner
ANTIBODY VALIDATION 101
Clone ID reveals the Source of Monoclonal Antibodies