Endothelin 1 (EDN1) Rat Monoclonal Antibody [Clone ID: 3G10]

CAT#: BM113

Endothelin 1 (EDN1) rat monoclonal antibody, clone 3G10, Purified

Specifications

Product Data

• Clone Name: 3G10
• Applications: IHC, R
• Recommended Dilution: RIA / IRMA.
  Immunohistochemistry on frozen sections:
  Frozen sections processed with dry acetone are recommended. Paraformaldehyde is not recommended as it destroys the epitope.
• Reactivities: Human
• Host: Rat
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: Synthetic human endothelin-C terminal fragment, conjugated to BSA
• Specificity: Reacts with the C-terminal of endothelins 1, 2 and 3.
  3G10 does not react with the endothelin precursor molecule, big endothelin.
• Formulation: PBS, containing 0.09% sodium azide
  State: Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein G affinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: endothelin 1
• Database Link:
  Entrez Gene 1906 Human
  UniProt ID P05305
• Background: Endothelins are potent vasoconstrictors and critical components in the progression of pulmonary arterial hypertension a devastating and rapidly progressive condition that leads to right ventricular strain and dysfunction.
• Synonyms: ET-3, Preproendothelin-3, PPET3, Preproendothelin-1, Big endothelin-1, Endothelin1, PPET1, EDN1, EDN2, Endothelin-2, ET-2, Preproendothelin-2, PPET2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Melanogenesis