Dpysl2 Rabbit Polyclonal Antibody

CAT#: AP54858SU-N

Dpysl2 rabbit polyclonal antibody, Serum

Product Images

Immunoblot analysis of the specificity of CRMP2 antibody Cat.-No AP54858SU-N using E.coli lysate transformed with cDNA of Human CRMP2

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  Distribution patternof CRMP2 in olfactory receptor neurons within the olfactory mucosa

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution:

  ELISA.
  Western Blot: 1/2000.
  Immunohistochemistry: 1/500.

• Reactivities: Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A 15 residue synthetic peptide derived from C-terminal domain of Human Collapsing-Response Mediator.
• Specificity: This antibody reacts with 65 kDa CRMP-2.
  It do not react with CRMP-1, CRMP-3, CRMP-4 or CRMP-5.
• Formulation: State: Serum
  State: Lyophilized serum
  Preservative: None
• Reconstitution Method: Restore in distilled water.
• Conjugation: Unconjugated
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: dihydropyrimidinase-like 2
• Database Link:
  Entrez Gene 12934 Mouse
  UniProt ID O08553
• Background: CRMP2 is 62 kDa member of the dehydropyrimidinase family. It is involved in axon formation and outgrowth by transporting to axons, the actin cytoskeleton regulating; Rac1-associated protein 1 (Sra-1)/WASP family verprolin-homologous protein 1 (WAVE1) complex. CRMP2 also regulates axon formation and branching by binding tubulin heterodimers thereby enhancing microtubule polymerisation. Through its interaction with ROKalpha, CRMP2 is also thought to play a role in RhoA-dependent signalling. CRMP2 is associated with mesial temporal lobe epilepsy and schizophrenia.
• Synonyms: Dihydropyrimidinase-related protein 2, DRP-2, N2A3