Uroplakin Ia (UPK1A) (C-term) Rabbit Polyclonal Antibody

CAT#: AP54475PU-N

Uroplakin Ia (UPK1A) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of UPK1A Antibody (C-term) in K562 cell line lysates (35 ug/lane). UPK1A (arrow) was detected using the purified Pab.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1:1;000.
  Western blot: 1:100~500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 197~227 amino acids from the C-terminal region of human UPK1A
• Specificity: This antibody detects Uroplakin-1a (UPK1A) (C-term).
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: uroplakin 1A
• Database Link:
  Entrez Gene 11045 Human
  UniProt ID O00322
• Background: The protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
• Synonyms: UP1a, Uroplakin Ia, UPIa, UPKa, Tetraspanin-21, TSPAN21, Tspan-21
• Note: Molecular Weight: 28879 Da

Reference Data

• Protein Families: Transmembrane