PION (GSAP) (C-term) Rabbit Polyclonal Antibody

CAT#: AP53308PU-N

PION (GSAP) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of PION / GSAP (C-term) Antibody (C-term) in NCI-H292 cell line lysates (35ug/lane). This demonstrates the PION antibody detected the PION protein (arrow).

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  Immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle reacted withPION / GSAP (C-term) Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PION
• Specificity: This antibody recognizes Human PION (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: gamma-secretase activating protein
• Database Link:
  Entrez Gene 54103 Human
  UniProt ID A4D1B5
• Background: Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).
• Synonyms: Gamma-secretase-activating protein, Protein pigeon homolog
• Note: Molecular Weight: 97802 Da

Reference Data

• Protein Families: Druggable Genome