GRPR (Center) Rabbit Polyclonal Antibody

CAT#: AP51959PU-N

GRPR (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of GRPR Antibody (Center) in HL-60 cell line lysates (35ug/lane). GRPR (arrow) was detected using the purified Pab.

• 

  Immunohistochemistry analysis in formalin fixed and paraffin embedded brain tissue reacted with GRPR Antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/50-1/100.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 123~152 amino acids from the Central region of Human Gastrin-releasing peptide receptor
• Specificity: This antibody recognizes Human Gastrin-releasing peptide receptor (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: gastrin releasing peptide receptor
• Database Link:
  Entrez Gene 2925 Human
  UniProt ID P30550
• Background: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
• Synonyms: GRP-R, GRPR, GRP-preferring bombesin receptor
• Note: Molecular Weight: 43199 Da

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Neuroactive ligand-receptor interaction