GCDH (C-term) Rabbit Polyclonal Antibody

CAT#: AP51799PU-N

GCDH (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of GCDH (arrow) using GCD / GCDH Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GCDH gene.

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  Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with GCD / GCDH Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 335-365 amino acids from the C-terminal region of Human GCD / GCDH
• Specificity: This antibody recognizes Human GCD / GCDH (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: glutaryl-CoA dehydrogenase
• Database Link:
  Entrez Gene 2639 Human
  UniProt ID Q92947
• Background: The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Synonyms: Glutaryl-CoA dehydrogenase
• Note: Molecular Weight: 48127 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Fatty acid metabolism, Lysine degradation, Metabolic pathways, Tryptophan metabolism