EGF (Center) Rabbit Polyclonal Antibody
EGF (Center) rabbit polyclonal antibody, Aff - Purified
|Recommended Dilution||ELISA: 1/1000.
Western Blot: 1/100 - 1/500.
|Immunogen||KLH conjugated synthetic peptide between 689-720 amino acids from the Central region of human EGF|
|Specificity||This antibody reacts to EGF.|
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.09% (W/V) sodium azide
|Purification||Affinity chromatography on Protein A|
Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
|Stability||Shelf life: one year from despatch.|
|Predicted Protein Size||133994 Da|
|Gene Name||Homo sapiens epidermal growth factor (EGF), transcript variant 1|
|Background||This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.|
|Synonyms||Urogastrone, Epidermal growth factor, URG, HOMG4|
|Protein Families||Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transmembrane|
|Protein Pathways||Bladder cancer, Cytokine-cytokine receptor interaction, Endocytosis, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton|