CGBP (CXXC1) (Center) Rabbit Polyclonal Antibody

CAT#: AP51152PU-N

CGBP (CXXC1) (Center) rabbit polyclonal antibody, Aff - Purified


USD 560.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications WB
Recommended Dilution This antibody is suitable for Western blottung.
The suggested dilution is 1/100-1/500.
Reactivities Human, Mouse
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide from the central region (between 325-354 aa) of Human CpG-binding protein/CXXC1.
Specificity This antibody detects CpG-binding protein/CXXC1 (Center).
Formulation PBS with 0.09% (W/V) Sodium Azide.
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Purified through a protein A column; followed by peptide affinity purification.
Conjugation Unconjugated
Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.

Stability Shelf life: one year from despatch.

Gene Name Homo sapiens CXXC finger protein 1 (CXXC1), transcript variant 1
Background Human CpG binding protein (hCGBP) contains three cysteine-rich domains, two of which
exhibit homology to the plant homeodomain finger domain and the third cysteine-rich
domain conforms to the CXXC motif identified in DNA methyltransferase, human trithorax,
and methyl-CpG binding domain protein 1. A fragment of hCGBP that contains the CXXC
domain binds to an oligonucleotide probe containing a single CpG site, and this complex is
disrupted by distinct oligonucleotide competitors that also contain a CpG motif(s). CBGP
plays an important part in embryonic viability and peri-implantation development. Native
hCGBP is detected as an 88-kDa protein by Western analysis and is ubiquitously
expressed. CGBP trans-activates promoters that contain CpG motifs but not promoters in
which the CpG is ablated suggesting that hCGBP is a transcriptional activator that
recognizes unmethylated CpG dinucleotides.
Synonyms CXXC1, CFP1, CGBP, PCCX1, PHF18
Note Molecular Weight: 75712 Da
Reference Data
Protein Families Druggable Genome, Transcription Factors

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.