CGBP (CXXC1) (Center) Rabbit Polyclonal Antibody
Other products for "CGBP"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | This antibody is suitable for Western blottung. The suggested dilution is 1/100-1/500. |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | KLH conjugated synthetic peptide from the central region (between 325-354 aa) of Human CpG-binding protein/CXXC1. |
Specificity | This antibody detects CpG-binding protein/CXXC1 (Center). |
Formulation | PBS with 0.09% (W/V) Sodium Azide. State: Aff - Purified State: Liquid purified Ig fraction |
Concentration | lot specific |
Purification | Purified through a protein A column; followed by peptide affinity purification. |
Conjugation | Unconjugated |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens CXXC finger protein 1 (CXXC1), transcript variant 1 |
Database Link | |
Background | Human CpG binding protein (hCGBP) contains three cysteine-rich domains, two of which exhibit homology to the plant homeodomain finger domain and the third cysteine-rich domain conforms to the CXXC motif identified in DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. A fragment of hCGBP that contains the CXXC domain binds to an oligonucleotide probe containing a single CpG site, and this complex is disrupted by distinct oligonucleotide competitors that also contain a CpG motif(s). CBGP plays an important part in embryonic viability and peri-implantation development. Native hCGBP is detected as an 88-kDa protein by Western analysis and is ubiquitously expressed. CGBP trans-activates promoters that contain CpG motifs but not promoters in which the CpG is ablated suggesting that hCGBP is a transcriptional activator that recognizes unmethylated CpG dinucleotides. |
Synonyms | CXXC1, CFP1, CGBP, PCCX1, PHF18 |
Note | Molecular Weight: 75712 Da |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
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