beta Catenin (CTNNB1) (C-term) Rabbit Polyclonal Antibody

CAT#: AP51124PU-N

Reviews ()
Write a review

beta Catenin (CTNNB1) (C-term) rabbit polyclonal antibody, Aff - Purified


Product Datasheet for 'AP51124PU-N'


 Cited in 5 publications.

USD 450.00


Availability*
2 Weeks

Size
    • 400 ul


Product images

Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution ELISA: 1/1000.
Western Blot: 1/100-1/500. 
Immunofluorescence: 1/10-1/50.
Immunohistochemistry on Paraffin Sections: 1/10-1/50.
Reactivity Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 653-681 amino acids from the C-terminal region of Human Catenin beta-1.
Specificity This antibody recognizes Human Catenin beta-1 (C-term). 
Formulation PBS
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.09% Sodium Azide
Concentration lot specific
Purification Affinity Chromatography on Protein A
Gene Name Homo sapiens catenin beta 1 (CTNNB1), transcript variant 2
Background
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Synonyms CTNNB1, CTNNB, Beta-catenin
Note Molecular Weight: 85497 Da
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
Protein Pathways Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Focal adhesion, Leukocyte transendothelial migration, Melanogenesis, Pathogenic Escherichia coli infection, Pathways in cancer, Prostate cancer, Thyroid cancer, Tight junction, Wnt signaling pathway

Citations (5)

Other products for "CTNNB1"
Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Antibody Performance Guarantee banner
ANTIBODY VALIDATION 101
Clone ID reveals the Source of Monoclonal Antibodies