Cytochrome C Oxidase subunit VIb (COX6B1) (C-term) Rabbit Polyclonal Antibody
Cytochrome C Oxidase subunit VIb (COX6B1) (C-term) rabbit polyclonal antibody, Aff - Purified
|Recommended Dilution||ELISA: 1/1000.
Western blot: 1/100 - 1/500.
Immunohistochemistry on paraffin sections: 1/10 - 1/50.
|Immunogen||KLH conjugated synthetic peptide between 58-86 amino acids from the C-terminal region of human COX6B1|
|Specificity||This antibody reacts to COX6B1.|
State: Aff - Purified
State: Liquid purified Ig fraction
Preservative: 0.09% (W/V) sodium azide
|Purification||Affinity chromatography on Protein A|
Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
|Stability||Shelf life: one year from despatch.|
|Predicted Protein Size||10192 Da|
|Gene Name||Homo sapiens cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) (COX6B1)|
|Background||Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively.|
|Synonyms||Cytochrome c oxidase subunit 6B1, COX6B1, COX6B, Mitochondria Complex IV|
|Protein Pathways||Alzheimer's disease, Cardiac muscle contraction, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease|