Coilin (COIL) (Center) Rabbit Polyclonal Antibody

CAT#: AP51008PU-N

Coilin (COIL) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

COIL Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the COIL antibody detected the COIL protein (arrow).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western blot: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 156-186 amino acids from the Central region of human COIL
• Specificity: This antibody reacts to COIL.
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 62608 Da
• Gene Name: coilin
• Database Link:
  Entrez Gene 8161 Human
  UniProt ID P38432
• Background: The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
• Synonyms: COIL, CLN80, p80

Reference Data

• Protein Families: Stem cell - Pluripotency