GRK3 (N-term) Rabbit Polyclonal Antibody

CAT#: AP50100PU-N

GRK3 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of ADRBK2 (arrow) using rabbit polyclonal ADRBK2 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ADRBK2 gene (Lane 2)

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  Formalin-fixed and paraffin-embedded human brain tissue reacted with ADRBK2 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western blotting: 1/100 - 1/500.
  Immunohistochemistry: 1/50 - 1/100.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 36~65 amino acids from the N-terminal region of human ADRBK2
• Specificity: This antibody reacts to Beta-ARK-2.
• Formulation: PBS containing 0.09% (W/V) sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: G protein-coupled receptor kinase 3
• Database Link:
  Entrez Gene 157 Human
  UniProt ID P35626
• Background: ADRBK2 is the beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
• Synonyms: Beta-adrenergic receptor kinase 2, BARK2, GRK3
• Note: Molecular Weight: 79710 Da

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Chemokine signaling pathway, Endocytosis, Olfactory transduction