stabilin1 (STAB1) (C-term) Goat Polyclonal Antibody

CAT#: AP33007PU-N

stabilin1 (STAB1) (C-term) goat polyclonal antibody, Aff - Purified

Product Images

Staining of paraffin embedded Human Spleen using Stabilin 1 Antibody at 3.8 ug/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: Peptide ELISA: 1/8000 (Detection Limit).
  Immunohistochemistry on Paraffin Sections: 3-5 µg/ml. In paraffin embedded Human Spleen shows endothelial staining.
• Reactivities: Bovine, Canine, Human, Porcine
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Peptide with sequence C-DFPDTQRILTVK, from the C Terminus of the protein sequence according to NP_055951.2.
• Specificity: This antibody recognizes Stabilin-1 at C-term.
• Formulation: Tris saline, pH~7.3
  State: Aff - Purified
  State: Liquid purfied Ig fraction
  Stabilizer: 0.5% BSA
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Antigen Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: stabilin 1
• Database Link:
  Entrez Gene 23166 Human
  UniProt ID Q9NY15
• Background: Stabilin-1 is a large transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes (Entrez gene 23166). Cellular localization: Membrane; Single-pass type I membrane protein.
• Synonyms: Stabilin-1, FEEL1, FEEL-1, CLEVER-1, KIAA0246