ACAT1 Rabbit Polyclonal Antibody
ACAT1 rabbit polyclonal antibody, Aff - Purified
|Recommended Dilution||Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
Western Blot: 1/1000 - 1/4000.
|Reactivity||Human, Mouse, Porcine, Rat|
|Specificity||This Polyclonal antibody is directed against Human ACAT1 protein.
Cross-reactivity with ACAT1 from other sources has not been determined.
|Formulation||PBS, pH 7.4 containing 0.02% Sodium Azide as preservative
State: Aff - Purified
State: Liquid purified Ig fraction
|Purification||Affinity Chromatography on Protein A|
|Storage||Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Gene Name||Homo sapiens acetyl-CoA acetyltransferase 1 (ACAT1)|
|Background||ACAT1 mRNA encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. The ACAT gene spans approximately 27 kb and contains 12 exons interrupted by 11 introns. Defects in this gene are associated with the alpha-methylacetoaceticaciduria disorder, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.|
|Synonyms||ACAT; MAT; T2; THIL|
|Protein Families||Druggable Genome|
|Protein Pathways||Butanoate metabolism, Fatty acid metabolism, Lysine degradation, Metabolic pathways, Propanoate metabolism, Pyruvate metabolism, Synthesis and degradation of ketone bodies, Terpenoid backbone biosynthesis, Tryptophan metabolism, Valine, leucine and isoleucine degradation|