Tnni3 pSer43 Rabbit Polyclonal Antibody

CAT#: AP26443PU-N

Tnni3 pSer43 rabbit polyclonal antibody, Aff - Purified


USD 513.00

3 Days*

Size
    • 100 ul

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Specifications

Product Data
Applications WB
Recommended Dilution Western blot: 1:1000. Immunolabeling is greatly decreased with lambda -phosphatase treatment.
Reactivities Canine, Human, Mouse, Primate, Rat, Xenopus, Zebrafish
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser 43 of mouse troponin I, cardiac (cTnI)
Specificity Specific for the ~25k cardiac troponin I protein phosphorylated at Ser 43.
Formulation 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg per ml BS A and 50% glycerol
State: Aff - Purified
State: Liquid ig fraction
Purification Affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns
Conjugation Unconjugated
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Troponin I (TnI) is 1 of 3 subunits, along with troponin C (TnC) and Troponin T (TnT) of troponin complex found in cardiac (cTnI) an d fast skeletal (fsTnI) muscle (Noland et al, 1995). Protein kinase C-mediated phosphorylation of cardiac myofilament proteins has been shown to depress the actomyosin interaction and may be important duri ng heart failure. (Montgomery et al, 2002) Studies indicate that phosphorylation of Ser 43 and Ser 45 of cardiac troponin I plays a substantial role in the PKC- mediated depression. (Montgomery et al, 2002).
Synonyms TNNI3, TNNC1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.