Lactoferrin (LTF) Bovine Polyclonal Antibody

CAT#: AP26407PU-N

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Lactoferrin (LTF) bovine polyclonal antibody, Purified



USD 425.00


Availability*
2 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Applications ELISA, IP, WB
Recommended Dilution Immunoassays (coating and detection).
Immunoprecipitation.
Western blot: The typical starting working dilution is 1:50.
Reactivity Human
Host Bovine
Isotype IgG
Clonality Polyclonal
Specificity This antibody detects Lactoferrin.
Formulation PBS
State: Purified
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% bovine serum albumin
Preservative: 0.02% sodium azide
Concentration lot specific
Purification Protein A
Storage

Store at 2 - 8 °C.

Stability Shelf life: one year from despatch.

Gene Name lactotransferrin
Background

Human lactoferrin (LF) is an 80 kDa glycoprotein which was first isolated from human milk. It plays an important part in the immune system and helps to fight infections. Lactoferrin promotes the health of the gastro-intestinal system by improving the intestinal microbial balance. In addition, LF can be found in epithelia and most body fluids and secretions.
Lactoferrin is secreted in plasma by neutrophils. Its plasma concentration also represents a positive relation to the total pool of neutrophils and the rate of neutrophil turnover. In inflammation lactoferrin is released from secondary granules of neutrophilic leukocytes into the extracellular medium. Therefore the extracellular lactoferrin concentration can be used as an index for neutrophil activation.
Lactoferrin strongly binds to iron and this iron binding property is considered to be an important antimicrobial. Human lactoferrin binds to bacterial products through its highly positively charged N-terminus, it kills various bacteria, most probably by inducing intracellular changes in these bacteria without affecting the membrane permeability. Cleavage by pepsin of lactoferrin leads to the release of lactoferricin H. This 47 amino acid peptide has more antimicrobial activity than its precursor and it can inhibit the classical but not the alternative complement pathway.
Lactoferrin also plays a role in signal transduction, immunomodulation and has antiadhesive, anticancer, antiviral activity.

Synonyms LTF, LF, Lactoferrin, EC=3.4.21, Talalactoferrin
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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