CBLL1 Rabbit Polyclonal Antibody

CAT#: AP26398PU-N

CBLL1 rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: Immunohistochemistry on frozen sections: The typical starting working dilution is 1:50.
  Immunoflourescence: The typical starting working dilution is 1:50.
  Western blot: The typical starting working dilution is 1:50.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Specificity: This antibody reacts with human Hakai, a c-Cbl-like protein.
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% bovine serum albumin
  Preservative: 0.02% sodium azide
• Concentration: lot specific
• Purification: Protein A
• Conjugation: Unconjugated
• Storage:

  Store at 2 - 8 °C.
  

• Stability: Shelf life: one year from despatch.

• Database Link:
  Entrez Gene 79872 Human
  UniProt ID Q75N03
• Background: Hakai is an E-cadherin binding protein, which has been identified as an E3 ubiquitin-ligase. Hakai contains SH2, RING, zinc-finger and proline-rich domains. Hakai interacts with E-cadherin in a tyrosine phosphorylation-dependent manner, inducing ubiquitination of the E-cadherin complex. Expression of Hakai in epithelial cells disrupts cell-cell contacts and enhances endocytosis of E-cadherin and cell motility. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai is able to control epithelial-mesenchymal transitions under physiological and pathological conditions.
• Synonyms: HAKAI, c-Cbl-like protein 1, RING finger protein 188