HIP2(UBE2K) Goat Polyclonal Antibody
Goat Polyclonal Anti-UBE2K Antibody, Purified
Product Datasheet for 'AP23819PU-N'
|Recommend Dilution||IHC, ELISA, WB|
|Immunogen||Synthetic peptide (C-SWDVETATELLLSN) from C-terminus of human HIP2|
|Formulation||Tris saline buffer, pH 7.3 containing 0.5% BSA as stabilizer and 0.02% sodium azide as preservative|
|Predicted Protein Size||22.2KDa|
|Gene Name||ubiquitin conjugating enzyme E2 K|
|Background||The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].|
|Protein Families||Transcription Factors, Druggable Genome|
|Protein Pathways||Ubiquitin mediated proteolysis|
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